The Eastern Cooperative Oncology Group ECOG undertook a phase III trial comparing tamoxifen versus tamoxifen plus OFS in premenopausal women with node negative, hormone receptor positive primary invasive breast cancers who did not receive adjuvant chemotherapy Phase III Comparison of Tamoxifen v Tamoxifen With Ovarian Ablation in Premenopausal Women With Axillary Node Negative Receptor Positive Breast Cancer 3 cm; E 3193, INT 0142
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